Armoring T-Cells Against Oxidative Stress Breaking Through the Solid Tumor Barrier for Adoptive Cell Therapies
- How Reactive Oxygen Species (ROS) impact the immune function of various immune effector cells
- Ex vivo activation of the Nrf2 pathway triggers a strong protection of cytotoxic lymphocytes against oxidative stress
- Perspectives for improving clinical efficacy in solid tumors for NK-, CAR-T cells and TIL therapybased approaches