Damien Zanker
Head of Clinical Manufacturing Cartherics Pty Ltd
Seminars
Wednesday 16th September 2026
How Long Is Long Enough? Rethinking mRNA for In Vivo CAR-T
12:10 pm
- Addressing the in vivo CAR-T tradeoff between durable CAR expression and safety
- Using data from primary human T cells and in vivo models to explore mRNA expression
- Exploring how cap structures, UTR design, and poly(A) tail engineering can deliver what in vivo CAR-T demands: not peak height, but duration
