Cell Therapy Fundamentals Day: Tuesday, September 23

Understanding the Basics of Cell Therapy Development from Discovery to Manufacturing to Gain a Holistic Overview

9:00 am Going Back to What Cell Therapy Actually Is & How it Helps Fight Oncological & Non- Oncological Indications

  • Sapna Chhagan Executive Director, Clinical Sciences, Cell Therapy, Early Clinical Development, Bristol Myers Squibb

Synopsis

  • Learning the basics of cell biology and how it can be modified to combat cancer and autoimmune diseases
  • Exploring how CAR-T and TCR cells work

9:30 am Exploring the Different Cell Types & Their Advantages in Targeting Tumors to Ensure Success

Synopsis

  • Comparing NK cells, TILs, Gamma Delta cells, Macrophages and more
  • Understanding the best cell type for your development

10:00 am Learning the Basics of Cell Therapy Manufacturing to Understand How it Affects Costs & Development Timelines

  • Yan Wang Director & Head of Cellular Process Development, Regeneron

Synopsis

  • Reviewing the 101 of cell product manufacturing
  • Establishing how manufacturing processes affect cell therapy success

10:30 am Morning Networking Break

Navigating Results & Outcomes of Cell Therapies to Understand the Reason Behind Key Successes & Failures

11:00 am Analyzing All Cell Therapy Successes to Date to Gain an Overview of What Has Worked & Why

  • Peter Gergely Global Head of Immunology, Translational Medicine, Novartis

Synopsis

  • Reviewing cell therapy success against hematological tumors and solid tumors
  • Identifying the effect of cell therapy on autoimmune indications to widen the scope

11:30 am Reviewing the Failures & Problems Over the Years to Know What to Avoid When Developing Your Own Cell Therapy Product

  • Brent Chesson Associate Director, Process Development, Immatics

Synopsis

  • Exploring why the cell therapy industry has had multiple failures in the last few years
  • Benchmarking failures with certain cell types to understand which ones to avoid

12:00 pm Networking Lunch

Exploring the Basics of Cell Therapy Engineering Technologies to Reduce Off-Target Toxicities & Increase Safety

1:00 pm Understanding What Cell Armoring is & How it Helps Improve Efficacy of Cell Therapy

Synopsis

  • Reviewing the basics of cell armoring and understanding how it can improve safety and efficacy
  • Assessing multiple cell armoring technologies such as CRISPR gene editing and enhancement for cytokine secretions and their advantages

1:30 pm Implementing Combination Technologies to Cell Therapy Development to Increase Safety & Durability

  • Ketki Vispute Associate Director - Cell Manufacturing Chemistry & Controls, Autolus

Synopsis

  • Reviewing the different combination technologies currently utilized such as antibody combinations, BTK inhibitors, immunomodulatory drugs and more
  • Determining the best combination technologies for cell therapy success

Mapping the Way Forward with Next Generation Technologies to Remain at the Front of Innovation & Be Best in Class

2:30 pm Afternoon Networking Break

3:00 pm Mapping Out the Existing Next Generation Technologies & The Ones on the Horizon to Select the One Most Appropriate for Your Cell Therapy Product

  • Xiuyan Wang Director, Cell Therapy Engineering, Memorial Sloan Kettering Cancer Center

Synopsis

  • Exploring the current landscape of next generation technologies
  • Understanding the science & applications of the next generation technologies

3:30 pm Roundtable Discussion: Reviewing the Need for Next Generation Technologies to Understand their Effect on Progressing the Field

Synopsis

  • Exploring the latest advancements with gene editing and armoring to increase tumor specificity
  • Examining the value of next generation cell therapy development in fighting hard to treat diseases
  • Tailoring next generation technologies to enhance safety and efficacy

4:00 pm End of Cell Therapy Fundamentals Day